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cholesterol 2

cholesterol oxidase 2

CHO-K1 cell 1

IVF-ET 1

NADPH oxidase 1

PCOS 1

ROS 1

Young’s modulus 1

atomic force microscopy 1

bioconversion 1

cancer therapy 1

cell proliferation 1

electrochemical biosensor 1

free radicals 1

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metal-enzyme hybridization 1

methyl-β-cyclodextrin 1

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Self-assembly of metal-cholesterol oxidase hybrid nanostructures and application in bioconversion of

Yu Xin, Qiuyue Gao, Yu Gu, Mengyao Hao, Guangming Fan, Liang Zhang

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 3,   Pages 615-629 doi: 10.1007/s11705-020-1989-7

Abstract: A cholesterol oxidase (COD) was hybridized with Ca , Zn , Al , Fe and Mn .Using steroid derivatives as substrates, this enzyme could convert cholesterol, pregnenolone, dehydroepiandrosterone

Keywords： cholesterol oxidase     metal-enzyme hybridization     nanostructures     sterol derivatives     bioconversion    

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DNA-reduced graphene oxide nanocomposites based electrochemical biosensor for highly sensitive detection of cholesterol

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 6,   Pages 1572-1582 doi: 10.1007/s11705-021-2112-4

Abstract: The as-prepared nanocomposites were applied as substrates for the construction of cholesterol oxidaseThe modified gold nanoparticles could further catalyze the products of cholesterol oxidation catalyzedby cholesterol oxidase, which was beneficial to the enzyme-catalyzed reaction.The as-fabricated bioelectrode exhibited excellent electrocatalytic performance for the cholesterol withthe electrochemical biosensor showed good selectivity and acceptable accuracy for the detection of cholesterol

Keywords： reduced graphene oxide     gold nanoparticles     electrochemical biosensor     cholesterol oxidase     cholesterol    

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Insight into the role of cholesterol in modulation of morphology and mechanical properties of CHO-K1

Lei Zhang, Lisha Zhao, Ping-Kai Ouyang, Pu Chen

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 1,   Pages 98-107 doi: 10.1007/s11705-018-1775-y

Abstract:

Cholesterol plays a significant role in the organization of lipids and modulation of membrane dynamicsHowever, the effect of cholesterol depletion on the eukaryotic cell membranes seems controversial.In this study, the effects of cholesterol on the topography and mechanical behaviors of CHO-K1 cellsHere, we found that the depletion of cholesterol in cell membranes could increase the membrane stiffnessrestoration could reverse the effect of cholesterol depletion on the membrane stiffness.

Keywords： cholesterol     methyl-β-cyclodextrin     atomic force microscopy     Young’s modulus     CHO-K1 cell    

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NADPH oxidase and reactive oxygen species as signaling molecules in carcinogenesis

Gang WANG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 1-7 doi: 10.1007/s11684-009-0018-5

Abstract: Intracellular ROS could be generated in reduced nicotinamide-adenine dinucleotidephosphate (NADPH) oxidase-dependentand/or NADPH oxidase-independent manners.One classical example is that ROS derived from the NADPH oxidase and released in neurotrophils are ablepathways in regulation of tumor growth, invasion and metastasis, and focuses on the role of the NADPH oxidase-derived

Keywords： free radicals     tumor     phox     cell proliferation     cancer therapy    

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Oxidative stress in granulosa cells contributes to poor oocyte quality and IVF-ET outcomes in women with polycystic ovary syndrome

Qiaohong Lai, Wenpei Xiang, Qing Li, Hanwang Zhang, Yufeng Li, Guijin Zhu, Chengliang Xiong, Lei Jin

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 518-524 doi: 10.1007/s11684-017-0575-y

Abstract: The increased ROS levels in GCs caused GC apoptosis, whereas NADPH oxidase 2 (NOX2) specific inhibitorsNADPH oxidase pathway may be involved in the mechanism of ROS production in GCs of women with PCOS.

Keywords： PCOS     ROS     granulosa cell     IVF-ET     NADPH oxidase    

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Title Author Date Type Operation

Self-assembly of metal-cholesterol oxidase hybrid nanostructures and application in bioconversion of

Yu Xin, Qiuyue Gao, Yu Gu, Mengyao Hao, Guangming Fan, Liang Zhang

Journal Article

DNA-reduced graphene oxide nanocomposites based electrochemical biosensor for highly sensitive detection of cholesterol

Journal Article

Insight into the role of cholesterol in modulation of morphology and mechanical properties of CHO-K1

Lei Zhang, Lisha Zhao, Ping-Kai Ouyang, Pu Chen

Journal Article

NADPH oxidase and reactive oxygen species as signaling molecules in carcinogenesis

Gang WANG

Journal Article

Oxidative stress in granulosa cells contributes to poor oocyte quality and IVF-ET outcomes in women with polycystic ovary syndrome

Qiaohong Lai, Wenpei Xiang, Qing Li, Hanwang Zhang, Yufeng Li, Guijin Zhu, Chengliang Xiong, Lei Jin

Journal Article